Variant Transthyretin in Blood Circulation Can Transverse the Blood-Cerebrospinal Barrier: Qualitative Analyses of Transthyretin Metabolism in Sequential Liver Transplantation1

These findings suggest that the variant TTR can cross-the blood-CSF barrier and migrate into CSF from blood circulation. Because leptomeningeal amyloidosis occurs in FAP ATTR Val30 Met as the progression of the disease, this information suggests that in addition to peripheral neuropathy, disorders of the central nervous system (CNS) should be given an attention in patients who underwent sequential liver transplantation using an explanted FAP ATTR Val30 Met patient's liver.