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July 14, 2018Gut

Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis

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Authors

TWTsung-Ru WuChang Gung UniversityCLChuan-Sheng LinSinovac BiotechCCChih‐Jung ChangHuaqiao University

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Implication

Preclinical investigation reveals anti-obesity effects of Hirsutella sinensis polysaccharides via Parabacteroides goldsteinii, indicating novel prebiotic and probiotic therapies for metabolic disease.

Key Points

  • Determine the functional role of the gut bacterium Parabacteroides goldsteinii in mediating the anti-obesity and anti-diabetic effects of Hirsutella sinensis polysaccharides.
  • Assessed the therapeutic potential of polysaccharides isolated from Hirsutella sinensis mycelium (HSM).
  • Evaluated metabolic and anti-obesity responses to the commensal gut bacterium Parabacteroides goldsteinii as a probiotic agent.
  • Identified Parabacteroides goldsteinii as playing a predominant role in driving the anti-obesity actions of Hirsutella sinensis polysaccharides.
  • Demonstrated that HSM polysaccharides and P. goldsteinii function effectively as prebiotic and probiotic agents for managing obesity and type 2 diabetes.

Cite This Study

Wu et al. (2018) studied this question.

synapsesocial.com/papers/69d80b793eff0c9dfaae3245https://doi.org/10.1136/gutjnl-2017-315458
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