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June 10, 2020Journal of the American Society of NephrologyOpen Access

Uremic Toxic Blood-Brain Barrier Disruption Mediated by AhR Activation Leads to Cognitive Impairment during Experimental Renal Dysfunction

Mickaël Bobot Laurent F. Thomas Anaïs Moyon Samantha Fernandez Nathalie McKay Laure Balasse Philippe Garrigue Pauline Brige Sophie Chopinet Stéphane Poitevin Claire Cérini Philippe Brunet Françoise Dignat‐George Stéphane Burtey Benjamin Guillet Guillaume Hache

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Abstract

AhR activation by indoxyl sulfate, a uremic toxin, leads to blood-brain barrier disruption associated with cognitive impairment in animal models of CKD.

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Bobot et al. (2020) studied this question.

synapsesocial.com/papers/69d80c1238c00da8b4bed868 https://doi.org/10.1681/asn.2019070728

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