What question did this study set out to answer?

To review the decade-long prevalence trends, molecular antimicrobial resistance pathways, and virulence evolution of sequence type 11 (ST11) carbapenem-resistant Klebsiella pneumoniae.

September 21, 2020SHILAP Revista de lepidopterologíaOpen Access

Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: A review over the last 10 years

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Authors

WLWenjian LiaoNanchang University YLYang LiuNanchang University WZWei ZhangHebei Medical University

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Implication

Surveillance review reveals rapid virulence acquisition among ST11 carbapenem-resistant Klebsiella pneumoniae strains, indicating urgent public health risks from hypervirulent superbugs.

Key Points

To review the decade-long prevalence trends, molecular antimicrobial resistance pathways, and virulence evolution of sequence type 11 (ST11) carbapenem-resistant Klebsiella pneumoniae.
Synthesized 10-year surveillance findings from the China Antimicrobial Surveillance Network (CHINET) and molecular epidemiology literature.
Analyzed plasmid dynamics, focusing on IncF plasmids, non-Tn4401 elements (NTE_KPC), and pLVPK-like virulence plasmids.
ST11 CRKP represents the dominant multidrug-resistant clone in China, underpinned by strong linkage among IncF plasmids, NTE_KPC, and the ST11 core genome.
Acquisition of pLVPK-like virulence plasmids via conjugative hybrid plasmids routinely converts ST11 CRKP into hypervirulent strains capable of causing severe infections in healthy hosts.

Cite This Study

Liao et al. (2020) studied this question.

synapsesocial.com/papers/69d80cd761e2ce1627d18a02 https://doi.org/10.1016/j.jgar.2020.09.004

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Implication

Surveillance review reveals rapid virulence acquisition among ST11 carbapenem-resistant Klebsiella pneumoniae strains, indicating urgent public health risks from hypervirulent superbugs.

Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: A review over the last 10 years

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Implication

Key Points

Cite This Study

Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: A review over the last 10 years

Discussion

Member takes

Implication

Key Points

Cite This Study

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