Replication and virulence in pigs of the first African swine fever virus isolated in China

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Why the study?

African swine fever entered China in August 2018 and rapidly spread across the country, severely threatening the domestic pig population.

Population

Specific-pathogen-free pigs and contact pigs

Comparison

Intramuscular inoculation with different virus dosages (10^3.5-10^6.5 HAD50) vs contact exposure

Design

Preclinical animal inoculation and contact-transmission study

Authors

Discussion

High-virulence Chinese ASFV warrants intensified swine biosecurity; leaves open field validation and control strategies.

Population

Specific-pathogen-free pigs and primary porcine alveolar macrophages (PAMs)

Intervention

Intramuscular inoculation with African swine fever virus (ASFV) isolate Pig/Heilongjiang/2018 (Pig/HLJ/18) at dosages of 10^3.5-10^6.5 HAD50

Comparator

Contact pigs (uninoculated pigs placed in contact with inoculated pigs)

Outcome

Virulence and transmissibility (incubation period, mortality, viremia, and viral shedding)

The first ASFV isolate in China (Pig/HLJ/18) is highly virulent and transmissible in domestic pigs, causing acute disease and 100% mortality.

Zhao et al. (2019) studied this question.

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