LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro2006 · 174 citations
2. 2A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo2006 · 180 citations
3. 3Modest but Reproducible Inhibition of Human Immunodeficiency Virus Type 1 Infection in Macrophages following LEDGFp75 Silencing2006 · 43 citations
4. 4Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus2006 · 212 citations
5. 5Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering2005 · 174 citations