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August 1, 2003Journal of Biological ChemistryOpen Access

LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

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Authors

GMGoedele N. MaertensImperial College LondonPCPeter CherepanovThe Francis Crick InstituteWPWim PluymersRega Institute for Medical Research

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Maertens et al. (2003) studied this question.

synapsesocial.com/papers/69d80e15ec670a5632d17ca5https://doi.org/10.1074/jbc.m303594200
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Zn2+ Promotes the Self-Association of Human Immunodeficiency Virus Type-1 Integrase in Vitro1997 · 170 citations
  2. 2The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection1986 · 1,827 citations
  3. 3Nuclear Localization of Human Immunodeficiency Virus Type 1 Preintegration Complexes (PICs): V165A and R166A Are Pleiotropic Integrase Mutants Primarily Defective for Integration, Not PIC Nuclear Import2002 · 96 citations
  4. 4Oligomerization within Virions and Subcellular Localization of Human Immunodeficiency Virus Type 1 Integrase1999 · 81 citations