De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism

Jinwen Yu; Zhiyu Liu; Wen Jiang; Guansong Wang; Chengde Mao

doi:10.1038/ncomms6724

January 30, 2015Nature CommunicationsOpen Access

De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism

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Key Points

Design a rigid, de novo RNA building block capable of homo-oligomerizing into a discrete, uniform nanostructure without requiring multiple unique strand sequences.
Engineered a geometrically defined de novo RNA tile designed to self-assemble into a closed 3D prism.
Characterized assembly uniformity and structural architecture using gel electrophoresis, atomic force microscopy, and cryogenic electron microscopy.
The engineered RNA tile successfully self-assembled into a uniform homo-octameric nanoprism rather than a polydisperse mixture of complexes.
High-resolution imaging confirmed that single-sequence homo-oligomerization achieved well-defined structural geometry comparable to advanced DNA nanostructures.

Implication

Molecular design study demonstrates self-assembly of uniform homo-octameric RNA nanoprisms from a single building block, indicating potential to achieve DNA-level structural control.

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Cite This Study

Yu et al. (2015) studied this question.

synapsesocial.com/papers/69d80fb25c3030ff03d18f11 https://doi.org/10.1038/ncomms6724

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De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism

Key Points

Implication

Discussion

Cite This Study

De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism

Key Points

Implication

Discussion

Cite This Study

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