Heat-Stable Carbetocin in the Management of Postpartum Haemorrhage in Low- and Middle-Income Countries: A Comprehensive Review of Clinical Evidence, Cost-Effectiveness, Implementation Challenges and Adoption Strategies

Heat-stable carbetocin offers a viable, cost-effective uterotonic strategy in LMIC settings. Consistent training, supportive supervision, regulatory oversight, and domestic funding, including private sector investment, are critical to achieving widespread adoption of HSC in LMIC. Expanding HSC across resource-limited settings could substantially reduce PPH-related deaths and accelerate maternal survival goals.