What question did this study set out to answer?

Determine how self-reported alcohol intake, sex, and age predict the long-term risk of developing alcohol-induced liver disease and cirrhosis in the general population.

May 1, 1996HepatologyOpen Access

Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study

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Authors

UBUlrik BeckerStatens Serum Institut ADA DeisCopenhagen University Hospital TSThorkild I. A. SørensenPreventive Cardiology

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Implication

Prospective cohort study demonstrates dose-dependent liver disease risk from alcohol consumption in adults, indicating higher female vulnerability at lower thresholds.

Key Points

Determine how self-reported alcohol intake, sex, and age predict the long-term risk of developing alcohol-induced liver disease and cirrhosis in the general population.
Prospective population-based cohort study of 13,285 men and women aged 30 to 79 years followed for 12 years (130,558 person-years of observation).
Alcohol intake was quantified via self-administered questionnaires, and diagnoses of alcohol-induced liver disease (n = 261) and cirrhosis (n = 124) were tracked through hospital discharge records and death certificates.
Associations were analyzed using multiplicative Poisson regression models to evaluate dose-response across sexes and age groups.
The annual incidence rate of alcohol-induced cirrhosis was 0.2% in men and 0.03% in women.
The lowest relative risk of liver disease occurred at 1 to 6 beverages weekly, with risk significantly increasing (relative risk > 1) above 7 to 13 beverages per week in women and 14 to 27 beverages per week in men.
A dose-dependent increase in liver disease risk occurred in both sexes, but women exhibited a steeper risk curve and significantly higher relative risk at every intake level compared to men.

Cite This Study

Becker et al. (1996) studied this question.

synapsesocial.com/papers/69d814848c03fbaff8bed8ad https://doi.org/10.1002/hep.510230513

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Implication

Prospective cohort study demonstrates dose-dependent liver disease risk from alcohol consumption in adults, indicating higher female vulnerability at lower thresholds.

Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study

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Implication

Key Points

Cite This Study

Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study

Discussion

Member takes

Implication

Key Points

Cite This Study

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