February 16, 2018Nature CommunicationsOpen Access

Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

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Population

Mice

Comparison

Analysis of periosteal cells and Periostin gene… vs Bone marrow stromal cells and wild-type models

Design

Preclinical

Authors

Discussion

May support periosteal cells over BMSCs for bone regeneration; leaves open Periostin-targeted therapies for human fracture healing.

Population

Mice (specifically analyzing periosteal cells and bone marrow stromal cells/skeletal stem cells, including Periostin-deficient models)

Intervention

Analysis of periosteal cells (PCs) and Periostin gene deletion

Comparator

Bone marrow stromal cells (BMSCs) and wild-type models

Outcome

Bone regenerative potential, clonogenicity, growth, differentiation capacity, and fracture consolidationsurrogate

Periosteum contains skeletal stem cells with high bone regenerative potential that require Periostin for maintenance and response to injury.

Lageneste et al. (2018) studied this question.

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