Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans2005 · 166 citations
2. 2Adult mouse brain gene expression patterns bear an embryologic imprint2005 · 189 citations
3. 3Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA2004 · 128 citations
4. 4<i>POLG</i> mutations in neurodegenerative disorders with ataxia but no muscle involvement2004 · 261 citations