Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1A Direct Repeat Is a Hotspot for Large-Scale Deletion of Human Mitochondrial DNA1989 · 579 citations
2. 2Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number2004 · 250 citations
3. 3Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency2003 · 186 citations
4. 4Multiple 5′-Flanking Regions of the Human α-Skeletal Actin Gene Synergistically Modulate Muscle-Specific Expression1987 · 43 citations