What question did this study set out to answer?

Identify and experimentally validate novel antiphage and anti-mobile genetic element defense systems clustered within microbial genomic defense islands.

January 25, 2018ScienceOpen Access

Systematic discovery of antiphage defense systems in the microbial pangenome

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Authors

SDShany DoronWeizmann Institute of Science SMSarah MelamedWeizmann Institute of Science GOGal OfirMax Planck Institute for Biology

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Implication

Comparative genomic analysis uncovers ten novel antiphage and antiplasmid defense systems in bacteria, suggesting an ancient ancestry of innate immunity shared across domains of life.

Key Points

Identify and experimentally validate novel antiphage and anti-mobile genetic element defense systems clustered within microbial genomic defense islands.
Screened prokaryotic pangenomes for uncharacterized gene families consistently co-localized near known defense genes in defense islands.
Cloned and heterologously expressed candidate defense systems in model bacteria to systematically assess protection against phage challenge and plasmid transfer.
Identified and functionally validated nine previously uncharacterized antiphage systems and one antiplasmid system providing strong protection against foreign genetic invaders.
Demonstrated that several newly identified systems co-opted essential cellular components, including structural elements of flagella and condensin complexes, for immune function.
Uncovered shared molecular features indicating an ancient, common evolutionary origin for innate immunity mechanisms found across bacteria, plants, and animals.

Cite This Study

Doron et al. (2018) studied this question.

synapsesocial.com/papers/69d818703eff0c9dfaae3577 https://doi.org/10.1126/science.aar4120

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Implication

Comparative genomic analysis uncovers ten novel antiphage and antiplasmid defense systems in bacteria, suggesting an ancient ancestry of innate immunity shared across domains of life.

Systematic discovery of antiphage defense systems in the microbial pangenome

Discussion

Member takes

Implication

Key Points

Cite This Study

Systematic discovery of antiphage defense systems in the microbial pangenome

Discussion

Member takes

Implication

Key Points

Cite This Study

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