What question did this study set out to answer?

To evaluate whether gut microbial metabolic network reconstruction and fecal metabolic profiling can identify patients with inflammatory bowel disease likely to achieve clinical remission on anti-TNF therapy.

July 18, 2019GastroenterologyOpen Access

Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases

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Authors

KAKonrad AdenFachhochschule Kiel ARAteequr RehmanFirmenich (Switzerland)SWSilvio WaschinaFachhochschule Kiel

Discussion

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Implication

Metabolomic profiling demonstrates anti-TNF remission prediction in inflammatory bowel disease, highlighting gut microbial metabolism as a therapeutic biomarker.

Key Points

To evaluate whether gut microbial metabolic network reconstruction and fecal metabolic profiling can identify patients with inflammatory bowel disease likely to achieve clinical remission on anti-TNF therapy.
Reconstructed microbial metabolic networks and profiled fecal metabolites from patients with inflammatory bowel disease undergoing anti-tumor necrosis factor therapy.
Metabolic network reconstruction and fecal metabolic profiles correlate with clinical remission following anti-tumor necrosis factor therapy.
Microbial metabolic profiling captures disease heterogeneity to support biomarker-driven patient stratification in inflammatory bowel disease.

Cite This Study

Aden et al. (2019) studied this question.

synapsesocial.com/papers/69d8193552654bb436d17efc https://doi.org/10.1053/j.gastro.2019.07.025

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Implication

Metabolomic profiling demonstrates anti-TNF remission prediction in inflammatory bowel disease, highlighting gut microbial metabolism as a therapeutic biomarker.

Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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