April 12, 2018

β-catenin-activated hepatocellular carcinomas are addicted to fatty acids

Key Points

Key points are not available for this paper at this time.

Abstract

FAO induced by β-catenin oncogenic activation in the liver is the driving force of the β-catenin-induced HCC. Inhibiting FAO by genetic and pharmacological approaches blocks HCC development, showing that inhibition of FAO is a suitable therapeutic approach for CTNNB1-mutated HCC.

Demander à l'IA

Bookmark

Cite This Study

Senni et al. (Thu,) studied this question.

synapsesocial.com/papers/69d81a6352654bb436d17fdf https://doi.org/https://doi.org/10.1136/gutjnl-2017-315448

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver2002 · 71 citations
2Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators1995 · 1,648 citations
3Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells2015 · 33 citations
4Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production1980 · 1,463 citations
5Medical therapies for hepatocellular carcinoma: a critical view of the evidence2012 · 311 citations

Demander à l'IA

Bookmark