Approximately half of sarcomere protein mutation carriers with an initially negative screen develop hypertrophic cardiomyopathy over 15 years, emphasizing the need for long-term surveillance including CMR.
Following a first negative screening, approximately 50% of SP mutation carriers develop HCM over 15 years of follow-up. Male sex and an abnormal ECG are associated with a higher risk of developing HCM. Regular CMR should be considered in long-term screening.
Lorenzini et al. (Mon,) studied this question.
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