January 1, 2022Journal of the American College of Cardiology194 citationsOpen Access
Association of Lipoprotein(a) With Atherosclerotic Plaque Progression
Structured PICO
Is Lipoprotein(a) associated with accelerated progression of coronary low-attenuation plaque in patients with advanced stable coronary artery disease?
P
Population
Patients with advanced stable coronary artery disease
I
Intervention
Lipoprotein(a) [Exposure]
O
Outcome
Progression of coronary low-attenuation plaque (necrotic core)surrogate
Elevated Lp(a) is associated with accelerated progression of necrotic core plaque in stable CAD, providing mechanistic support for Lp(a) as a therapeutic target.
Abstract
Among patients with advanced stable coronary artery disease, Lp(a) is associated with accelerated progression of coronary low-attenuation plaque (necrotic core). This may explain the association between Lp(a) and the high residual risk of myocardial infarction, providing support for Lp(a) as a treatment target in atherosclerosis.