What question did this study set out to answer?

To assess the diagnostic utility and performance of NKX2.2 immunohistochemical staining in distinguishing Ewing sarcoma from other small round cell tumors.

March 23, 2012The American Journal of Surgical Pathology

NKX2.2 is a Useful Immunohistochemical Marker for Ewing Sarcoma

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Authors

AYAkihiko YoshidaNational Cancer Centre Japan SSShigeki SekineKeio University KTKoji TsutaKansai Medical University

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Implication

Diagnostic study demonstrates 93% sensitivity and 89% specificity for NKX2.2 in Ewing sarcoma, highlighting its utility in distinguishing small round cell tumors.

Key Points

To assess the diagnostic utility and performance of NKX2.2 immunohistochemical staining in distinguishing Ewing sarcoma from other small round cell tumors.
Immunostained tissue sections from 30 genetically confirmed Ewing sarcomas and 130 non-Ewing small round cell tumors using an antibody targeting NKX2.2.
Evaluated nuclear staining under light microscopy, defining positive expression as nuclear reactivity in at least 5% of tumor cells.
NKX2.2 was positive in 28 of 30 (93%) Ewing sarcomas, with all positive cases demonstrating diffuse staining (>50%) and 25 of 28 displaying moderate-to-strong intensity.
Nuclear expression occurred in 14 of 130 non-Ewing tumors, including all olfactory neuroblastomas and subsets of small cell carcinomas, synovial sarcomas, mesenchymal chondrosarcomas, and malignant melanomas.
Overall diagnostic performance of NKX2.2 for Ewing sarcoma yielded a sensitivity of 93% and a specificity of 89%.

Cite This Study

Yoshida et al. (2012) studied this question.

synapsesocial.com/papers/69d81c7c7392c8ce61bee8b2 https://doi.org/10.1097/pas.0b013e31824ee43c

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Implication

Diagnostic study demonstrates 93% sensitivity and 89% specificity for NKX2.2 in Ewing sarcoma, highlighting its utility in distinguishing small round cell tumors.

NKX2.2 is a Useful Immunohistochemical Marker for Ewing Sarcoma

Discussion

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Implication

Key Points

Cite This Study

NKX2.2 is a Useful Immunohistochemical Marker for Ewing Sarcoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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