April 7, 2017SHILAP Revista de lepidopterología207 citationsOpen Access
Patterns of care and outcomes of patients with METAstatic soft tissue SARComa in a real-life setting: the METASARC observational study
Structured PICO
P
Population
Patients with metastatic soft tissue sarcoma
I
Intervention
Patterns of care including doxorubicin combined with a second drug (e.g., ifosfamide), locoregional treatment, and best supportive care
In a real-life setting, doxorubicin combination therapy and locoregional treatments are valid options for metastatic soft tissue sarcoma, with TNT potentially serving as a surrogate for overall survival.
Abstract
The combination of doxorubicin with a second drug, such as ifosfamide, represents a valid option, particularly when tumor shrinkage is expected to provide clinical benefits. After failure of the second-line therapy, best supportive care should be considered, particularly in patients with non-leiomyosarcoma histology who are not eligible to participate in a clinical trial. Locoregional treatment of metastasis should always be included in the therapeutic strategy when feasible. TNT may represent a useful surrogate endpoint for OS in clinical studies.