Mendelian randomization study reveals an association between elevated serum urate levels and cardiac events in adults, indicating shared genetic pathways linking gout and cardiovascular risk.
In this study, high serum urate levels were found to be associated with increased risk of different types of cardiac events. The finding of genetic pleiotropy indicates the existence of common upstream pathological elements influencing both urate and metabolic traits, and this may suggest new opportunities and challenges for developing drugs targeting a common mediator that would be beneficial for both the treatment of gout and the prevention of cardiovascular comorbidities.
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Li et al. (2019) studied this question.
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