Population-based study shows relations of serum urate, renal function, and genetic risk to cardiovascular disease, suggesting implications for prevention strategies.
Key Points
Investigate associations of serum urate, renal function, and genetic risk with cardiovascular disease incidence.
Included 383,390 participants from the UK Biobank, free of cardiovascular diseases at baseline.
Assessed serum urate levels and kidney damage markers, and estimated glomerular filtration rate.
Calculated genetic risk scores for coronary heart disease and ischemic stroke; estimated hazard ratios using Cox models.
Documented 35,932 cardiovascular disease events during 13.24-year follow-up, including 30,025 coronary heart disease and 5,524 ischemic stroke cases.
Each standard deviation increase in urate was linked to increased risk for cardiovascular disease, coronary heart disease, and ischemic stroke.
Elevated urate combined with poor renal function or high genetic risk significantly increased cardiovascular disease risk.