Population
Computational model of sarcoplasmic reticulum (SR) calcium handling in cardiac cells
Design
Preclinical
Authors
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Model consistency with observed velocities bolsters in silico cardiac calcium research; leaves open human translation and clinical relevance.
A computational model demonstrates that calcium diffusion and calcium-induced calcium release can accurately predict the propagation velocities of calcium transients in cardiac cells.
Backx et al. (1989) studied this question.