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Collectively, this study found that the effect of probiotics in enhancing host resistance to pathogen infections depended on function of B₁₂ produced by an anaerobic indigenous gut microbe, Cetobacterium. Furthermore, as a gut microbial regulator, B₁₂ exhibited the ability to strengthen the interactions within gut microbiota and gut barrier tight junctions, thereby improving host resistance against pathogen infection. Video Abstract.
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Qi et al. (2023) studied this question.
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