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July 1, 1975CancerOpen Access

Combination chemotherapy of Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP

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Why the study?

Does ABVD improve complete remission compared to MOPP in patients with advanced Hodgkin's disease?

Population

60 patients with advanced Hodgkin's disease, with no prior chemotherapy; 20% relapsed after primary…

Comparison

ABVD vs MOPP

Design

RCT, Randomized to MOPP vs. ABVD

Authors

GBGianni BonadonnaUniversity of VeronaRZR ZucaliFondazione IRCCS Istituto Nazionale dei TumoriSMS. MonfardiniIstituto Oncologico Veneto

Discussion

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Implication

ABVD matches MOPP for complete remission in advanced Hodgkin lymphoma; confirms effective non-cross-resistant alternative for clinicians and researchers.

Structured PICO

Does ABVD improve complete remission compared to MOPP in patients with advanced Hodgkin's disease?

P
Population
60 patients with advanced Hodgkin's disease (45 evaluable for remission induction), with no prior chemotherapy; 20% relapsed after primary radiotherapy.
I
Intervention
ABVD (6 cycles of adriamycin, bleomycin, vinblastine, and imidazole carboxamide)
C
Comparator
MOPP
O
Outcome
Complete remission inductionsurrogate

ABVD is an effective alternative to MOPP for inducing complete remission in advanced Hodgkin's disease, with no cross-resistance observed.

Limitations

  • Lack of long-term followup

Cite This Study

Bonadonna et al. (1975) studied this question.

synapsesocial.com/papers/69d8240805ee2ba81dbef278https://doi.org/10.1002/1097-0142(197507)36:1<252::aid-cncr2820360128>3.0.co;2-7
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy1972 · 62 citations
  2. 2Combination Chemotherapy With Nitrogen Mustard, Vincristine, Procarbazine and Prednisone in Previously Treated Patients With Hodgkin’s Disease1970 · 61 citations
  3. 3MOPP chemotherapy for advanced Hodgkin's disease. Prognostic factors in 81 patients1973 · 71 citations
  4. 4Hodgkin’s Disease in Childhood1973 · 63 citations