What question did this study set out to answer?

This research aims to understand how FcγRIV affects the activities of IgG2a and IgG2b subclasses.

FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial reveals impaired IgG2a and IgG2b effector functions in FcγRIV-deficient mice, suggesting its central role.

This research aims to understand how FcγRIV affects the activities of IgG2a and IgG2b subclasses.
Generated FcγRIV-deficient mice to investigate IgG subclass activities in vivo.
Examined various effector functions related to IgG2a and IgG2b in models of autoimmunity and antibody-dependent cellular cytotoxicity.
Observed impaired IgG2a-dependent effector functions in FcγRIV-deficient mice.
Noted diminished IgG2b-dependent activities as well due to FcγRIV deletion.

Nimmerjahn et al. (2010) studied this question.

View Full Paper

Ask AI

Bookmark