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January 1, 1989Carcinogenesis

Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea

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Why the study?

Does green tea antioxidant fraction prevent cytotoxicity and inhibition of intercellular communication in cultured mouse hepatocytes and human keratinocytes?

Population

Cultured B6C3F1 mouse hepatocytes and human keratinocytes (NHEK cells)

Comparison

Green tea antioxidant fraction containing… vs Cells exposed to pro-oxidant compounds without GTA

Design

Preclinical

Authors

RRRandall J. RuchGeorgia Institute of TechnologySCShujun ChengNorthwest A&F UniversityJKJames E. KlaunigUniversity of Toledo Medical Center

Discussion

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Implication

GTA cytoprotection in hepatocyte models is hypothesis-generating; leaves open relevance to human carcinogenesis or clinical use.

Structured PICO

Does green tea antioxidant fraction prevent cytotoxicity and inhibition of intercellular communication in cultured mouse hepatocytes and human keratinocytes?

P
Population
Cultured B6C3F1 mouse hepatocytes and human keratinocytes (NHEK cells)
I
Intervention
Green tea antioxidant (GTA) fraction containing catechins (0.05-50 micrograms/ml)
C
Comparator
Cells exposed to pro-oxidant compounds without GTA
O
Outcome
Prevention of cytotoxicity and inhibition of intercellular communicationsurrogate

Green tea antioxidant fraction prevents cytotoxicity and inhibition of intercellular communication induced by pro-oxidant compounds in vitro, suggesting a mechanism for its anti-tumor promotion effects.

Cite This Study

Ruch et al. (1989) studied this question.

synapsesocial.com/papers/69d832ef8c03fbaff8bedf7dhttps://doi.org/10.1093/carcin/10.6.1003
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