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December 9, 2013Journal of Medicinal ChemistryOpen Access

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

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Authors

EHEdward J. HennessyModerna Therapeutics (United States)AAAmmar AdamCambridge Scientific (United States)BABrian AquilaAstraZeneca (United States)

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Hennessy et al. (2013) studied this question.

synapsesocial.com/papers/69d837a5f4e559c61eae2f06https://doi.org/10.1021/jm401075x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of apoptosis in the pathogenesis and treatment of diseases1996 · 81 citations
  2. 2Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity2011 · 43 citations
  3. 3Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP22011 · 105 citations