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April 4, 2011Journal of Medicinal ChemistryOpen Access

Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity

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Authors

HSHaiying SunChina Pharmaceutical UniversityLLLiu LiuKunming Medical UniversityJLJianfeng LüQingdao University

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Sun et al. (2011) studied this question.

synapsesocial.com/papers/6a70c5fefebe604dd7098933https://doi.org/10.1021/jm101651b
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  1. 1Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein2008 · 51 citations
  2. 2Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP2007 · 208 citations
  3. 3SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP2008 · 203 citations
  4. 4Apoptosis in cancer2000 · 1,888 citations
  5. 5Design, Synthesis, and Evaluation of a Potent, Cell-Permeable, Conformationally Constrained Second Mitochondria Derived Activator of Caspase (Smac) Mimetic2006 · 99 citations