What question did this study set out to answer?

To review the development history, structural mechanisms, and clinical applications of proteasome inhibitors in multiple myeloma and related diseases.

May 2, 2015Biochemical PharmacologyOpen Access

Proteasome inhibitors

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Authors

BTBeverly A. TeicherNational Cancer Institute JTJoseph E. TomaszewskiAmerican Society for Bone and Mineral Research

Discussion

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Implication

Review demonstrates the cytotoxic efficacy of targeted proteasome inhibitors in multiple myeloma, indicating expanding therapeutic utility across hematologic cancers.

Key Points

To review the development history, structural mechanisms, and clinical applications of proteasome inhibitors in multiple myeloma and related diseases.
Narrative synthesis of the 20-year translational trajectory of proteasome inhibitors from initial discovery to regulatory approval.
Comparative analysis of reversible boronic acid inhibitors (bortezomib, ixazomib, delanzomib) and irreversible epoxyketone inhibitors (carfilzomib, oprozomib).
Bortezomib and carfilzomib received FDA approval as potent cytotoxic agents, while ixazomib and oprozomib advanced into late-stage clinical evaluation.
Preclinical and clinical investigations confirmed that multiple myeloma cells exhibit disproportionately high sensitivity to proteasome inhibition relative to other tumor cell lines.
Therapeutic utility of proteasome inhibitors continues to drive hematologic malignancy regimens, with emerging evaluation in non-malignant indications.

Cite This Study

Teicher et al. (2015) studied this question.

synapsesocial.com/papers/69d842d2d56ca42147d17e85 https://doi.org/10.1016/j.bcp.2015.04.008

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Implication

Review demonstrates the cytotoxic efficacy of targeted proteasome inhibitors in multiple myeloma, indicating expanding therapeutic utility across hematologic cancers.

Proteasome inhibitors

Discussion

Member takes

Implication

Key Points

Cite This Study

Proteasome inhibitors

Discussion

Member takes

Implication

Key Points

Cite This Study

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