Experimental study demonstrates copper-catalyzed perfluoroalkylation and cyclization of unactivated alkenes, highlighting an atom-economical route to complex tricyclimidazoles.
A copper‐catalyzed cascade difunctionalization of unactivated olefins with readily available R f ‐I reagents to construct C sp 3 −CF 2 /C−C bonds has been reported. This strategy provides a convenient access to a variety of useful perfluoroalkylated tricyclimidazole derivatives in reasonable yields. Preliminary mechanistic studies indicate that the present reaction probably undergo a radical/SET (single electron transfer) pathway. The transformation features mild condition, simple operation, atomic economy, and broad substrate scope. magnified image
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Guo et al. (2022) studied this question.
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