A Placebo-Controlled Randomized Trial of Warfarin in Idiopathic Pulmonary Fibrosis
Why the study?
Does warfarin provide benefit in patients with progressive idiopathic pulmonary fibrosis?
Population
Patients with progressive idiopathic pulmonary fibrosis (IPF) who lacked other indications for anticoagulation
Comparison
Warfarin vs Placebo
Design
RCT, Randomized, Placebo-controlled
Authors
Discussion
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Implication
Warfarin should not be used in progressive IPF absent other anticoagulation indications; this RCT closes the hypothesis of net benefit.
Structured PICO
Does warfarin provide benefit in patients with progressive idiopathic pulmonary fibrosis?
P
Population
Patients with progressive idiopathic pulmonary fibrosis (IPF) who lacked other indications for anticoagulation
I
Intervention
Warfarin
C
Comparator
Placebo
Warfarin should not be used for the treatment of progressive idiopathic pulmonary fibrosis in patients without other indications for anticoagulation due to an increased risk of mortality.
Cite This Study
Noth et al. (2012) studied this question.