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November 14, 2003Statistics in Medicine

Simple procedures for blinded sample size adjustment that do not affect the type I error rate

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Authors

MKMeinhard KieserHeidelberg UniversityTFTim FriedeHeart Failure & Transplant

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Implication

Randomized trial demonstrates that blinded sample size adjustments maintain type I error rate and ensure power.

Key Points

  • The aim is to present procedures for adjusting sample size without violating the type I error rate during trials.
  • Analytical computations were performed to evaluate variance estimators.
  • Sample size adjustment procedures were analyzed under the t-test framework.
  • A more general method for permutation tests was discussed.
  • Using blind variance estimators does not affect the type I error rate of the t-test.
  • The procedures ensure desired statistical power even with initial variance misspecification.
  • The method maintains significance levels across various design settings.

Cite This Study

Kieser et al. (2003) studied this question.

synapsesocial.com/papers/69d84407a2a48916bbbefadbhttps://doi.org/10.1002/sim.1585
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