Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching

This is the authors' abstract. We don't add key points for this paper.

Tumour budding regions are characterised by a phenotype switch compared with the tumour bulk, involving the acquisition of migratory characteristics and a decrease in cell proliferation. In particular, most tumour budding signatures were EMT-positive and switched from an epithelial subtype (CMS2) in the tumour bulk to a mesenchymal subtype (CMS4) in budding cells.