Retrospective study finds tumor budding correlates with advanced stage and invasion in colorectal carcinoma, suggesting clinical significance.
The results of our study indicate that tumor budding is common in colorectal carcinoma and is significantly associated with advanced tumor stage, invasion, vascular and perineural invasion, and regional lymph node metastasis. Aberrant expression of EMT markers (β-catenin, E-cadherin, Snail, and ZEB1) was frequently observed, although no significant association with tumor budding was found.
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Bashar Al-Hassawi (2025) studied this question.
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