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May 13, 2013Proceedings of the National Academy of SciencesOpen Access

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

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Authors

AEAmandine EverardWalloon Excellence in Lifesciences and BiotechnologyCBClara BelzerLeiden UniversityLGLucie GeurtsNetherlands Institute for Art History

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Implication

Animal study demonstrates that viable Akkermansia muciniphila reverses diet-induced metabolic disorders and strengthens the gut barrier in mice, indicating therapeutic potential for obesity.

Key Points

  • To elucidate the physiological role of the mucus-degrading bacterium Akkermansia muciniphila in host-microbiota cross-talk, gut barrier integrity, and metabolic dysfunction in diet-induced obesity.
  • Assessed Akkermansia muciniphila levels in mice with genetic or diet-induced obesity and type 2 diabetes, both with and without dietary prebiotic supplementation.
  • Administered viable or heat-killed Akkermansia muciniphila daily to high-fat diet-fed mice to measure effects on adiposity, glucose tolerance, gut permeability, and tissue inflammation.
  • Akkermansia muciniphila abundance was depleted in obese and diabetic mice, but prebiotic feeding restored its abundance and improved the host metabolic profile.
  • Viable Akkermansia muciniphila supplementation reversed high-fat diet-induced fat-mass gain, metabolic endotoxemia, adipose tissue inflammation, and insulin resistance while elevating gut endocannabinoid levels.
  • Heat-killed bacterial cells failed to restore mucus layer thickness or correct metabolic dysfunction, indicating that functional benefits depend entirely on viable bacteria.

Cite This Study

Everard et al. (2013) studied this question.

synapsesocial.com/papers/69d84c2b8c03fbaff8beecefhttps://doi.org/10.1073/pnas.1219451110
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epithelial crosstalk at the microbiota–mucosal interface2010 · 584 citations
  2. 2Microbes inside—from diversity to function: the case of <i>Akkermansia</i>2012 · 734 citations
  3. 3Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice2008 · 4,844 citations
  4. 4Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue2011 · 328 citations