Why the study?
Does voluntary aerobic exercise reverse age-related carotid artery stiffening and adventitial collagen changes in mice?
Population
Old and young B6D2F1 mice, plus old mice undergoing exercise and cultured adventitial fibroblasts.
Comparison
10–14 weeks of modest voluntary wheel running… vs Cage control (no exercise).
Design
Preclinical
Follow-up
10-14 weeks
Authors
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May reverse age-related carotid stiffening in mice; leaves open human translation and clinical relevance.
Does voluntary aerobic exercise reverse age-related carotid artery stiffening and adventitial collagen changes in mice?
Voluntary aerobic exercise reverses age-related carotid artery stiffening in mice, associated with reductions in adventitial collagen and TGF-β1.
Fleenor et al. (2010) studied this question.
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