A mathematical model of macrophage activation post-MI was established to help understand mechanisms of left ventricular remodeling.
Model of post-MI macrophage balance may guide interventions; hypothesis-generating in animals only, requires clinical validation.
We have established and validated a mathematical model for macrophage activation post-MI. The stability analysis provided a possible strategy to intervene the balance of classically and alternatively activated macrophages in this study. The results will lay a strong foundation to understand the mechanisms of left ventricular remodelling post-MI.
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Wang et al. (2012) studied this question.
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