Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction
Population
Mice with myocardial infarction induced by ligature of the left anterior descending coronary artery
Comparison
Observation of macrophage activation post-MI vs LV-control
Design
Preclinical
Follow-up
10 days
Authors
Discussion
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Member takes
Implication
Macrophage shift post-MI may guide timed immunomodulation; leaves open clinical translation from this animal model.
Structured PICO
P
Population
Mice with myocardial infarction induced by ligature of the left anterior descending coronary artery
I
Intervention
Observation of macrophage activation post-MI
C
Comparator
LV-control
O
Outcome
Transcriptional profile and activation type of macrophages during scar tissue formationsurrogate
Macrophages undergo a phenotypic shift from classical to alternative activation during the transition from early inflammation to scar tissue formation after myocardial infarction.
Cite This Study
Troidl et al. (2009) studied this question.