Why the study?
Does IL-4 administration or M2-like macrophage supplementation improve cardiac repair and prognosis after myocardial infarction in adult mice?
Does IL-4 administration or M2-like macrophage supplementation improve cardiac repair and prognosis after myocardial infarction in adult mice?
M2-like macrophages are critical for cardiac repair after myocardial infarction, and stimulating their proliferation with IL-4 represents a potential therapeutic strategy to enhance post-MI healing.
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M2 macrophages may aid murine post-MI repair; hypothesis-generating for IL-4 therapy, with human translation untested.
Shiraishi et al. (2016) studied this question.
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