What question did this study set out to answer?

This research aims to explore the role of M2 macrophages in cardiac repair following myocardial infarction.

May 2, 2016Journal of Clinical InvestigationOpen Access

Alternatively activated macrophages determine repair of the infarcted adult murine heart

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Why the study?

Does IL-4 administration or M2-like macrophage supplementation improve cardiac repair and prognosis after myocardial infarction in adult mice?

Population

Adult murine model of myocardial infarction

Comparison

External supply of M2-like macrophages or IL-4… vs Control animals and untreated wild-type mice

Design

Preclinical

Authors

MSManabu ShiraishiTokyo Metropolitan Bokutoh Hospital YSYasunori ShintaniQueen Mary University of London YSYusuke ShintaniKurume University

Discussion

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Implication

M2 macrophages may aid murine post-MI repair; hypothesis-generating for IL-4 therapy, with human translation untested.

Key Points

This research aims to explore the role of M2 macrophages in cardiac repair following myocardial infarction.
Identified M2-like macrophages in the murine heart post-MI.
Compared heart repair in Trib1-/- mice with control animals.
Evaluated the effects of IL-4 administration on M2 macrophage levels and fibrosis.
Trib1-/- mice had catastrophic prognosis with increased cardiac rupture due to low collagen formation.
External supply of M2-like macrophages fully rescued tissue repair in Trib1-/- mice.
IL-4 administration significantly increased M2 macrophages and improved cardiac prognosis in WT mice.

Structured PICO

Does IL-4 administration or M2-like macrophage supplementation improve cardiac repair and prognosis after myocardial infarction in adult mice?

Population

Adult murine model of myocardial infarction (including wild-type mice and Trib1-/- mice lacking the kinase TRIB1, which exhibit selective depletion of M2 macrophages)

Intervention

External supply of M2-like macrophages (in Trib1-/- mice) or IL-4 administration (in wild-type mice)

Comparator

Control animals (for Trib1-/- mice) and untreated wild-type mice

Outcome

Post-myocardial infarction prognosis, cardiac rupture, and tissue repair (fibroblast activation and collagen fibril formation)surrogate

M2-like macrophages are critical for cardiac repair after myocardial infarction, and stimulating their proliferation with IL-4 represents a potential therapeutic strategy to enhance post-MI healing.

Cite This Study

Shiraishi et al. (2016) studied this question.

synapsesocial.com/papers/69d576e462196bac97d9bd1b https://doi.org/10.1172/jci85782

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Alternatively activated macrophages determine repair of the infarcted adult murine heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Alternatively activated macrophages determine repair of the infarcted adult murine heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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