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February 24, 2011Clinical Cancer Research

Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Are Expressed in Breast Cancer and Can Be Targeted to Inhibit Tumor Cell Survival

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Abstract

BDNF and NT-4/5 contribute to breast cancer cell survival and can serve as prospective targets in attempts to inhibit tumor growth.

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Cite This Study

Vanhecke et al. (2011) studied this question.

synapsesocial.com/papers/69d8823418b0ca7f91d1803b https://doi.org/10.1158/1078-0432.ccr-10-1890

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Nerve Growth Factor Stimulates Proliferation and Survival of Human Breast Cancer Cells through Two Distinct Signaling PathwaysOriginal Research · 2001 · 239 citations
2Tumor Necrosis Factor Receptor-associated Death Domain Protein Is Involved in the Neurotrophin Receptor-mediated Antiapoptotic Activity of Nerve Growth Factor in Breast Cancer CellsOriginal Research · 2003 · 67 citations
3BEX2 Is Overexpressed in a Subset of Primary Breast Cancers and Mediates Nerve Growth Factor/Nuclear Factor-κB Inhibition of Apoptosis in Breast Cancer Cell LinesOriginal Research · 2007 · 97 citations
4Manipulation of the nerve growth factor network in prostate cancerReview · 2007 · 44 citations
5The Dark Side of the NGF Family: Neurotrophins in NeoplasiasOriginal Research · 2006 · 101 citations