Cohort study reveals lower seizure freedom after failing multiple medications in pediatric drug-resistant epilepsy, highlighting benefits of timely surgical evaluation.
Initiation of surgical evaluation after failure of more than 2 ASMs is associated with more complex epilepsy phenotypes and lower rates of seizure freedom. However, 80% of these patients still experienced a >50% reduction in seizures, highlighting the therapeutic benefits of timely epilepsy surgery-even when seizure freedom is unlikely-regardless of epilepsy subtype.
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Samanta et al. (2025) studied this question.
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