ZDF rats exhibit oxidative stress and mitochondrial dysfunction in liver and brain tissues, providing insights into the pathophysiology of diabesity.
Provides preclinical insights into diabesity complications; leaves open human therapeutic translation.
Our data shows that, like other tissues, ZDF rat liver and brain develop complications associated with redox homeostasis and mitochondrial dysfunction. These results, thus, might have implications in understanding the etiology and pathophysiology of diabesity which in turn, would help in managing the disease associated complications.
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Raza et al. (2015) studied this question.
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