Diabetic bacterial infected wounds are severe complications in diabetic patients, posing significant challenges to clinical management. The wound site is prone to bacterial colonization and biofilm formation, triggering a persistent inflammatory response and forming a vicious cycle of "hyperglycemia-infection-inflammation". Therefore, the development of antibacterial materials that are efficient, safe, and less likely to induce drug resistance is of great significance for improving wound repair. In this study, a thermosensitive composite hydrogel based on chitosan (CS) and poloxamer (P407/P188), named CPP, was developed for the codelivery of berberine (BBR) and resveratrol (RES). This system undergoes a phase transition at physiological temperature to form a porous network structure, enabling controllable and sustained drug release. In vivo experiments using a diabetic mouse model with infected wounds showed that the CPP@BBR@RES hydrogel effectively inhibited bacterial colonization, alleviated the inflammatory response, and significantly promoted collagen deposition, angiogenesis, and wound closure. This study innovatively combines the thermogelling and sustained-release properties of the material with the synergistic antibacterial, anti-inflammatory, and repair-promoting functions of the dual drugs, providing a multifunctional integrated therapeutic strategy for diabetic infected wounds.
Chen et al. (2026) studied this question.