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June 14, 2026ACS Applied Bio Materials

Thermosensitive Multifunctional Hydrogel for Boosting Drug-Resistant Infected Diabetic Wound Healing by Integrating Gas Therapy and Cascaded CDT

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Authors

LSLiyu ShiLXLi XYMYunfei Mo

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Overview

Randomized trial demonstrates enhanced healing of infected diabetic wounds, suggesting a new treatment approach.

Key Points

  • This research aims to develop a multifunctional hydrogel to improve healing in diabetic wounds infected with drug-resistant bacteria.
  • Constructed a hydrogel using Pluronic F127 and hyaluronic acid, loaded with MIL-100(Fe), S-nitrosoglutathione, and glucose oxidase.
  • Evaluated antibacterial and anti-inflammatory properties in a hyperglycemic diabetic environment.
  • Assessed angiogenesis and collagen deposition through in vivo experiments.
  • MGG@FH hydrogel significantly reduces pro-inflammatory factors (TNF-α and IL-6) and increases the anti-inflammatory IL-10.
  • Enhanced angiogenesis and collagen deposition observed, accelerating wound healing.
  • Effectively conforms to wound shapes due to temperature-sensitive sol–gel transition.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4524b1cc60ccdea8a74chttps://doi.org/10.1021/acsabm.6c00462
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Application of metal-organic frameworks in infectious wound healing2024 · 62 citations
  2. 2Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis2025 · 7 citations