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November 10, 2025Advanced Healthcare MaterialsOpen Access

Multi‐Modal Therapy for Diabetic Ulcers: A Hydrogel Platform Combining Antibacterial, Oxygenating, ROS‐Scavenging, and Pro‐Healing Functions

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Authors

YLYang LiPZPeng ZhaoZFZhennan Fang

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Overview

Hydrogel therapy improves tissue regeneration and reduces inflammation in diabetic ulcers, suggesting benefits for wound management.

Key Points

  • The research aims to develop a hydrogel that integrates multiple therapeutic functions to treat diabetic ulcers and enhance healing.
  • Developed an injectable hydrogel using polyethylene glycol derivatives and ε-polylysine.
  • Loaded hydrogel with rMFG-E8 and HM-FA to target bacterial infections and oxidative stress.
  • Evaluated effects on wound closure and inflammatory responses in a diabetic ulcer mouse model.
  • Hydrogel exhibited good biocompatibility and significantly suppressed inflammatory responses.
  • Decreased reactive oxygen species and alleviated hypoxia in ulcer sites.
  • Significantly accelerated wound closure and promoted angiogenesis.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69253a29c0ce034ddc357632https://doi.org/10.1002/adhm.202503908
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Also Consider

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  5. 5Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair2026 · 3 citations