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April 15, 2026PharmaceuticsOpen Access

A Multifunctional ε-Polylysine/Hyaluronic Acid Hydrogel Promotes Diabetic Wound Healing by Orchestrating Multidimensional Synergy

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Authors

ZLZelong LiNingbo UniversityYWYiqin WangNingbo UniversityYZY. ZhouNingbo University

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Overview

Demonstrates hydrogel's effectiveness in healing diabetic wounds, suggesting improved management strategies.

Key Points

  • To evaluate the efficacy of a multifunctional hydrogel in promoting diabetic wound healing by addressing microenvironmental challenges.
  • Developed a hydrogel using methacrylic anhydride modified hyaluronic acid and ε-polylysine loaded with desferrioxamine.
  • Characterized physicochemical and biochemical properties of the hydrogel.
  • Tested the hydrogel's efficacy in a streptozotocin-induced hyperglycemic mouse model.
  • Hydrogel reduced oxidative stress damage and inhibited bacterial infection.
  • Achieved 80.8% DPPH radical scavenging efficiency and over 99.8% inhibition of bacterial growth.
  • Accelerated wound closure in diabetic mice to near completion by day 14.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b0130https://doi.org/10.3390/pharmaceutics18040473
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