What question did this study set out to answer?

To develop a multifunctional hydrogel that addresses immune dysregulation, infection, and angiogenesis in diabetic foot ulcer healing.

March 23, 2026Bioactive MaterialsOpen Access

Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair

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Authors

HLHaiyang Lin ZWZengguang Wang PLPing Li

Discussion

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Overview

Demonstrates a novel hydrogel platform that enhances healing by regulating immune response and promoting blood vessel formation in diabetic foot ulcers.

Key Points

To develop a multifunctional hydrogel that addresses immune dysregulation, infection, and angiogenesis in diabetic foot ulcer healing.
Designed a desferrioxamine-loaded Mn-doped zeolitic imidazolate framework-8.
Fabricated a glucose- and ROS-responsive chitosan-based hydrogel containing DFO@Mn-ZIF-8.
Tested in a validated S. aureus-infected diabetic wound model.
The hydrogel achieved dual roles in bacterial clearance and angiogenesis promotion.
Synergistically regulated macrophage polarization to improve the immune microenvironment.
Accelerated healing through activation of HIF-1α-VEGF, PI3K-Akt, and JAK-STAT pathways.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69c0df0bfddb9876e79c154d https://doi.org/10.1016/j.bioactmat.2026.03.034

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March 23, 2026Bioactive MaterialsOpen Access

Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair

View Full Paper

Ask AI

Bookmark

Authors

HLHaiyang Lin ZWZengguang Wang PLPing Li

Discussion

Member takes

Overview

Demonstrates a novel hydrogel platform that enhances healing by regulating immune response and promoting blood vessel formation in diabetic foot ulcers.

Key Points

To develop a multifunctional hydrogel that addresses immune dysregulation, infection, and angiogenesis in diabetic foot ulcer healing.
Designed a desferrioxamine-loaded Mn-doped zeolitic imidazolate framework-8.
Fabricated a glucose- and ROS-responsive chitosan-based hydrogel containing DFO@Mn-ZIF-8.
Tested in a validated S. aureus-infected diabetic wound model.
The hydrogel achieved dual roles in bacterial clearance and angiogenesis promotion.
Synergistically regulated macrophage polarization to improve the immune microenvironment.
Accelerated healing through activation of HIF-1α-VEGF, PI3K-Akt, and JAK-STAT pathways.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69c0df0bfddb9876e79c154d https://doi.org/10.1016/j.bioactmat.2026.03.034

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