Research shows DNA methylation affects ZDHHC24 expression in intracranial aneurysms, indicating new risk factors.
ZDHHC24 overexpression is causally linked to increased IA risk, and this relationship is mediated by specific DNA methylation loci. These findings underscore the roles of palmitoylation-related gene expression and DNA methylation in IA pathogenesis, offering novel insights into the molecular mechanisms underlying IA susceptibility.
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Yuan et al. (2026) studied this question.
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