Exploratory validation of TOpClass criteria shows high remission rates in perianal Crohn's disease, indicating a strong benchmark for clinical trials.
The TOpClass definition provides an internationally agreed and standardised MRI-based criteria for identifying a radiologically healed fistula in perianal Crohn's disease. 93% of patients who met the TOpClass criteria for a radiologically healed fistula achieved sustained clinical remission, with excellent inter-rater reliability. The TOpClass criteria offer a potential benchmark for clinical trials, where a radiologically healed fistula represents the aspirational gold standard, associated with long-term remission in perianal fistulising Crohn's disease.
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Anand et al. (2026) studied this question.
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